Loss of HDAC6 alters gut microbiota and worsens obesity.

ABSTRACT: Alterations in gut microbiota are known to affect intestinal inflammation and obesity. Antibiotic treatment can affect weight gain by elimination of histone deacetylase (HDAC) inhibitor-producing microbes, which are anti-inflammatory by augmenting regulatory T (T_reg) cells. We asked whether mice that lack HDAC6 and have potent suppressive T_reg cells are protected from microbiota-induced accelerated weight gain. We crossed wild-type and HDAC6-deficient mice and subjected the offspring to perinatal penicillin, inducing weight gain via microbiota disturbance. We observed that male HDAC6-deficient mice were not protected and developed profoundly accelerated weight gain. The antibiotic-exposed HDAC6-deficient mice showed a mixed immune phenotype with increased CD4⁺

SUBMITTER: Lieber AD 

PROVIDER: S-EPMC6355060 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature