Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice.

ABSTRACT: Insulin-like growth factors (IGFs) are essential for local skeletal muscle growth and organismal physiology, but these actions are entwined with glucose homeostasis through convergence with insulin signaling. The objective of this work was to determine whether the effects of IGF-I on growth and metabolism could be separated. We generated muscle-specific IGF-I-deficient (MID) mice that afford inducible deletion of Igf1 at any age. After Igf1 deletion at birth or in young adult mice, evaluations of muscle physiology and glucose homeostasis were performed up to 16 wk of age. MID mice generated at birth had lower muscle and circulating IGF-I, decreased muscle and body mass, and impaired muscle force production. Eight-wk-old male MID had heightened insulin levels with trends of elevated fasting

SUBMITTER: Vassilakos G 

PROVIDER: S-EPMC6355069 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature