GLANET: genomic loci annotation and enrichment tool.

ABSTRACT:

Motivation

Genomic studies identify genomic loci representing genetic variations, transcription factor (TF) occupancy, or histone modification through next generation sequencing (NGS) technologies. Interpreting these loci requires evaluating them with known genomic and epigenomic annotations.

Results

We present GLANET as a comprehensive annotation and enrichment analysis tool which implements a sampling-based enrichment test that accounts for GC content and/or mappability biases, jointly or separately. GLANET annotates and performs enrichment analysis on these loci with a rich library. We introduce and perform novel data-driven computational experiments for assessing the power and Type-I error of its enrichment procedure which show that GLANET has attained high statistical p

SUBMITTER: Otlu B 

PROVIDER: S-EPMC6355098 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature