MiR-206 inhibits proliferation, migration, and invasion of gastric cancer cells by targeting the MUC1 gene.

ABSTRACT:

Background

MicroRNAs (miRNAs) can regulate the post-transcriptional level of gene expression. It has been documented that downregulation of miR-206 is significant in human gastric cancer (GC), whereas its role in GC cell biological behaviors, including proliferation, migration, and invasion, has not been thoroughly investigated. MiR-206 levels have a negative association with lymph node metastasis and tumor invasion, and patients with higher miR-206 expression have better prognoses. Functional studies demonstrated that miR-206 overexpression significantly suppresses GC cell proliferation, migration, and invasion, and induces apoptosis in vitro.

Materials and methods

MiR-206 and MUC1 were determined by RNA extraction, quantitative real-time polymerase chain reaction, and luci

SUBMITTER: Deng M 

PROVIDER: S-EPMC6355168 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature