Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem.

ABSTRACT: Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralizing antibody responses against highly diverse epitopes within the "head" of the viral hemagglutinin (HA) protein. There is increasing interest in redirecting immunity toward the more conserved HA stem or stalk as a means of broadening protective antibody responses. Here we examined HA stem-specific B cell and T follicular helper (Tfh) cell responses in the context of influenza infection and immunization in mouse and monkey models. We found that during infection, the stem domain was immunologically subdominant to the head in terms of serum antibody production and antigen-specific B and Tfh cell responses. Similarly, we found that HA stem immunogens were poorly immunogenic compared with the ful

SUBMITTER: Tan HX 

PROVIDER: S-EPMC6355240 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature