Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism.

ABSTRACT:

Background

Intake of ω-3 PUFAs have been demonstrated to have positive effects on pregnancy outcome, whose receptor, GPR120, regulates several cellular functions including differentiation, metabolism and immune reaction. However, whether GPR120 is involved in decidualization and pregnancy remains unknown.

Methods

Decidua tissue from women with normal pregnancy and spontaneous abortion were collected to determine the expression profile of GPR120. Abortion mouse models and artificially induced deciduoma in mice were established to evaluate the effect of GPR120 on pregnancy outcome and in vivo decidualization. HESCs and primary DSCs were used to explore the roles of GPR120 in decidualization and mechanisms involved.

Findings

We found that GPR120 functioned to promote dec

SUBMITTER: Huang J 

PROVIDER: S-EPMC6355327 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature