Projected population-wide impact of antiretroviral therapy-linked isoniazid preventive therapy in a high-burden setting.

ABSTRACT:

Objective

Both isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) reduce tuberculosis risk in individuals living with HIV. We sought to estimate the broader, population-wide impact of providing a pragmatically implemented 12-month IPT regimen to ART recipients in a high-burden community.

Design

Dynamic transmission model of a tuberculosis (TB)-HIV epidemic, calibrated to site-specific, historical epidemiologic and clinical trial data from Khayelitsha, South Africa.

Methods

We projected the 5-year impact of delivering a 12-month IPT regimen community-wide to 85% of new ART initiators and 15%/year of those already on ART, accounting for IPT-attributable reductions in TB infection, progression, and transmission. We also evaluated scenarios of continuousl

SUBMITTER: Kendall EA 

PROVIDER: S-EPMC6355370 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature