Characterization of Two EF-hand Domain-containing Proteins from Toxoplasma gondii.

ABSTRACT: The universal role of calcium (Ca²⁺ ) as a second messenger in cells depends on a large number of Ca²⁺ -binding proteins (CBP), which are able to bind Ca²⁺ through specific domains. Many CBPs share a type of Ca²⁺ -binding domain known as the EF-hand. The EF-hand motif has been well studied and consists of a helix-loop-helix structural domain with specific amino acids in the loop region that interact with Ca²⁺ . In Toxoplasma gondii a large number of genes (approximately 68) are predicted to have at least one EF-hand motif. The majority of these genes have not been characterized. We report the characterization of two EF-hand motif-containing proteins, TgGT1_216620 and TgGT1_280480, which localize to the plasma membrane and to the rhoptr

SUBMITTER: Chang L 

PROVIDER: S-EPMC6355381 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature