Smoking-induced iron dysregulation in the lung.

ABSTRACT: Iron is one of the most abundant transition elements and is indispensable for almost all organisms. While the ability of iron to participate in redox chemistry is an essential requirement for participation in a range of vital enzymatic reactions, this same feature of iron also makes it dangerous in the generation of hydroxyl radicals and superoxide anions. Given the high local oxygen tensions in the lung, the regulation of iron acquisition, utilization, and storage therefore becomes vitally important, perhaps more so than in any other biological system. Iron plays a critical role in the biology of essentially every cell type in the lung, and in particular, changes in iron levels have important ramifications on immune function and the local lung microenvironment. There is substantial eviden

SUBMITTER: Zhang WZ 

PROVIDER: S-EPMC6355389 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature