Self-assembly and soluble aggregate behavior of computationally designed coiled-coil peptide bundles.

ABSTRACT: Coiled-coil peptides have proven useful in a range of materials applications ranging from the formation of well-defined fibrils to responsive hydrogels. The ability to design from first principles their oligomerization and subsequent higher order assembly offers their expanded use in producing new materials. Toward these ends, homo-tetrameric, antiparallel, coiled-coil, peptide bundles have been designed computationally, synthesized via solid-phase methods, and their solution behavior characterized. Two different bundle-forming peptides were designed and examined. Within the targeted coiled coil structure, both bundles contained the same hydrophobic core residues. However, different exterior residues on the two different designs yielded sequences with different distributions of charged res

SUBMITTER: Haider MJ 

PROVIDER: S-EPMC6355460 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature