T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma.

ABSTRACT: Primary testicular lymphoma is a rare lymphoid malignancy, most often, histologically, representing diffuse large B-cell lymphoma. The tumor microenvironment and limited immune surveillance have a major impact on diffuse large B-cell lymphoma pathogenesis and survival, but the impact on primary testicular lymphoma is unknown. Here, the purpose of the study was to characterize the tumor microenvironment in primary testicular lymphoma, and associate the findings with outcome. We profiled the expression of 730 immune response genes in 60 primary testicular lymphomas utilizing the Nanostring platform, and used multiplex immunohistochemistry to characterize the immune cell phenotypes in the tumor tissue. We identified a gene signature enriched for T-lymphocyte markers differentially expressed b

SUBMITTER: Leivonen SK 

PROVIDER: S-EPMC6355505 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature