Blood-brain barrier permeability measured using dynamic contrast-enhanced magnetic resonance imaging: a validation study.

ABSTRACT:

Key points

The blood-brain barrier (BBB) is an important and dynamic structure which contributes to homeostasis in the central nervous system. BBB permeability changes occur in health and disease but measurement of BBB permeability in humans is not straightforward. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to model the movement of gadolinium contrast into the brain, expressed as the influx constant K_i . Here evidence is provided that K_i as measured by DCE-MRI behaves as expected for a marker of overall BBB leakage. These results support the use of DCE-MRI for in vivo studies of human BBB permeability in health and disease.

Abstract

Blood-brain barrier (BBB) leakage can be measured using dynamic contrast-enhanced magnetic

SUBMITTER: Varatharaj A 

PROVIDER: S-EPMC6355631 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature