STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice.

ABSTRACT: Mammals possess a remarkable ability to sense subtle temperature deviations from the thermoneutral skin temperature of ~33 °C, which ensures precise warm sensation. However, the underlying mechanisms remain unclear. Here we show that STIM1, an endoplasmic reticulum (ER) resident transmembrane protein that responds to both ER Ca²⁺ depletion and heat, mediates temperature-induced Ca²⁺ influx in skin keratinocytes via coupling to Orai Ca²⁺ channels in plasma membrane. Behaviorally, the keratinocyte-specific knockout of STIM1 shifts the optimal preference temperature (OPT) of mice from ~32 °C to ~34 °C, resulting in a strikingly reversed preference between 32 °C and 34 °C. Importantly, the thermally inactive STIM1-ΔK knock-in mice show altered OPT and warm pref

SUBMITTER: Liu X 

PROVIDER: S-EPMC6355819 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature