Siglec genes confer resistance to systemic lupus erythematosus in humans and mice.

ABSTRACT: A recent meta-analysis revealed the contribution of the SIGLEC6 locus to the risk of developing systemic lupus erythematosus (SLE). However, no specific Siglec (sialic acid-binding immunoglobulin-like lectin) genes (Siglecs) have been implicated in the pathogenesis of SLE. Here, we performed in silico analysis of the function of three major protective alleles in the locus and found that these alleles were expression quantitative trait loci that enhanced expression of the adjacent SIGLEC12 gene. These data suggest that SIGLEC12 may protect against the development of SLE in Asian populations. Consistent with human genetic data, we identified two missense mutations in lupus-prone B6.NZM^{Sle1/Sle2/Sle3} (Sle1-3) mice in Siglece, which is the murine Siglec with the greatest homology to

SUBMITTER: Flores R 

PROVIDER: S-EPMC6355849 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature