Colloidal Gels with Tunable Mechanomorphology Regulate Endothelial Morphogenesis.

ABSTRACT: Endothelial morphogenesis into capillary networks is dependent on the matrix morphology and mechanical properties. In current 3D gels, these two matrix features are interdependent and their distinct roles in endothelial organization are not known. Thus, it is important to decouple these parameters in the matrix design. Colloidal gels can be engineered to regulate the microstructural morphology and mechanics in an independent manner because colloidal gels are formed by the aggregation of particles into a self-similar 3D network. In this work, gelatin based colloidal gels with distinct mechanomorphology were developed by engineering the electrostatic interaction mediated aggregation of particles. By altering the mode of aggregation, colloidal gels showed either compact dense microstructure o

SUBMITTER: Nair SK 

PROVIDER: S-EPMC6355882 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature