Dataset Information

The antimicrobial potential of Streptomyces from insect microbiomes.

ABSTRACT: Antimicrobial resistance is a global health crisis and few novel antimicrobials have been discovered in recent decades. Natural products, particularly from Streptomyces, are the source of most antimicrobials, yet discovery campaigns focusing on Streptomyces from the soil largely rediscover known compounds. Investigation of understudied and symbiotic sources has seen some success, yet no studies have systematically explored microbiomes for antimicrobials. Here we assess the distinct evolutionary lineages of Streptomyces from insect microbiomes as a source of new antimicrobials through large-scale isolations, bioactivity assays, genomics, metabolomics, and in vivo infection models. Insect-associated Streptomyces inhibit antimicrobial-resistant pathogens more than soil Streptomyces. Genomics and metabolomics reveal their diverse biosynthetic capabilities. Further, we describe cyphomycin, a new molecule active against multidrug resistant fungal pathogens. The evolutionary trajectories of Streptomyces from the insect microbiome influence their biosynthetic potential and ability to inhibit resistant pathogens, supporting the promise of this source in augmenting future antimicrobial discovery.

SUBMITTER: Chevrette MG

PROVIDER: S-EPMC6355912 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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The antimicrobial potential of Streptomyces from insect microbiomes.

Chevrette Marc G MG Carlson Caitlin M CM Ortega Humberto E HE Thomas Chris C Ananiev Gene E GE Barns Kenneth J KJ Book Adam J AJ Cagnazzo Julian J Carlos Camila C Flanigan Will W Grubbs Kirk J KJ Horn Heidi A HA Hoffmann F Michael FM Klassen Jonathan L JL Knack Jennifer J JJ Lewin Gina R GR McDonald Bradon R BR Muller Laura L Melo Weilan G P WGP Pinto-Tomás Adrián A AA Schmitz Amber A Wendt-Pienkowski Evelyn E Wildman Scott S Zhao Miao M Zhang Fan F Bugni Tim S TS Andes David R DR Pupo Monica T MT Currie Cameron R CR

Nature communications 20190131 1

Antimicrobial resistance is a global health crisis and few novel antimicrobials have been discovered in recent decades. Natural products, particularly from Streptomyces, are the source of most antimicrobials, yet discovery campaigns focusing on Streptomyces from the soil largely rediscover known compounds. Investigation of understudied and symbiotic sources has seen some success, yet no studies have systematically explored microbiomes for antimicrobials. Here we assess the distinct evolutionary ...[more]

PMID: 30705269

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Dataset Information

The antimicrobial potential of Streptomyces from insect microbiomes.

Publications

The antimicrobial potential of Streptomyces from insect microbiomes.

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