Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi H
PROVIDER: S-EPMC6355926 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Takahashi Haruko H Yumoto Kenji K Yasuhara Kazuma K Nadres Enrico T ET Kikuchi Yutaka Y Buttitta Laura L Taichman Russell S RS Kuroda Kenichi K
Scientific reports 20190131 1
The discovery of anticancer therapeutics effective in eliminating dormant cells is a significant challenge in cancer biology. Here, we describe new synthetic polymer-based anticancer agents that mimic the mode of action of anticancer peptides. These anticancer polymers developed here are designed to capture the cationic, amphiphilic traits of anticancer peptides. The anticancer polymers are designed to target anionic lipids exposed on the cancer cell surfaces and act by disrupting the cancer cel ...[more]