Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency.

ABSTRACT:

Background

Inflammation is the most relevant mechanism linking obesity with insulin-resistance and metabolic disease. It impacts the structure and function of tissues and organs involved in metabolism, such as the liver, pancreatic islets and the hypothalamus. Brown adipose tissue has emerged as an important component of whole body energy homeostasis, controlling caloric expenditure through the regulation of non-shivering thermogenesis. However, little is known about the impact of systemic inflammation on the structure and function of brown adipose tissue.

Methods

The relations between IL10 and mitochondria structure/function and also with thermogenesis were evaluated by bioinformatics using human and rodent data. Real-time PCR, immunoblot, fluorescence and transmission elec

SUBMITTER: de-Lima-Junior JC 

PROVIDER: S-EPMC6355943 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature