Analysis of chemical exchange saturation transfer contributions from brain metabolites to the Z-spectra at various field strengths and pH.

ABSTRACT: Chemical exchange saturation transfer (CEST) exploits the chemical exchange of labile protons of an endogenous or exogenous compound with water to image the former indirectly through the water signal. Z-spectra of the brain have traditionally been analyzed for two most common saturation phenomena: downfield amide proton transfer (APT) and upfield nuclear Overhauser enhancement (NOE). However, a great body of brain metabolites, many of interest in neurology and oncology, contributes to the downfield saturation in Z-spectra. The extraction of these "hidden" metabolites from Z-spectra requires careful design of CEST sequences and data processing models, which is only possible by first obtaining CEST signatures of the brain metabolites possessing labile protons. In this work, we measured excha

SUBMITTER: Khlebnikov V 

PROVIDER: S-EPMC6355971 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature