A Cell Proliferation and Inflammatory Signature Is Induced by Lawsonia intracellularis Infection in Swine.

ABSTRACT: Lawsonia intracellularis causes porcine proliferative enteropathy. This is an enteric disease characterized by thickening of the wall of the ileum that leads to decreased growth of animals and diarrhea. In this study, we investigated the host response to L. intracellularis infection by performing transcriptomic and pathway analysis of intestinal tissue samples from groups of infected and noninfected animals at 14, 21, and 28 days postchallenge. At the peak of infection, when animals developed the most severe lesions, infected animals had higher levels of several gene transcripts involved in cellular proliferation and inflammation, including matrix metalloproteinase-7 (MMP7), transglutaminase-2 (TGM2), and oncostatin M (OSM). Histomorphology also revealed general features of intestinal infl

SUBMITTER: Leite FL 

PROVIDER: S-EPMC6355989 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature