Investigating functional brain network integrity using a traditional and novel categorical scheme for neurodevelopmental disorders.

ABSTRACT:

Background

Current diagnostic systems for neurodevelopmental disorders do not have clear links to underlying neurobiology, limiting their utility in identifying targeted treatments for individuals. Here, we aimed to investigate differences in functional brain network integrity between traditional diagnostic categories (autism spectrum disorder [ASD], attention-deficit/hyperactivity disorder [ADHD], typically developing [TD]) and carefully consider the impact of comorbid ASD and ADHD on functional brain network integrity in a sample adequately powered to detect large effects. We also assess the neurobiological separability of a novel, potential alternative categorical scheme based on behavioral measures of executive function.

Method

Five-minute resting-state fMRI data were ob

SUBMITTER: Dajani DR 

PROVIDER: S-EPMC6356009 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature