Tissue tension and not interphase cell shape determines cell division orientation in the Drosophila follicular epithelium.

ABSTRACT: We investigated the cell behaviors that drive morphogenesis of the Drosophila follicular epithelium during expansion and elongation of early-stage egg chambers. We found that cell division is not required for elongation of the early follicular epithelium, but drives the tissue toward optimal geometric packing. We examined the orientation of cell divisions with respect to the planar tissue axis and found a bias toward the primary direction of tissue expansion. However, interphase cell shapes demonstrate the opposite bias. Hertwig's rule, which holds that cell elongation determines division orientation, is therefore broken in this tissue. This observation cannot be explained by the anisotropic activity of the conserved Pins/Mud spindle-orienting machinery, which controls division orientation

SUBMITTER: Finegan TM 

PROVIDER: S-EPMC6356066 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature