Mitochondrial DNA variants and pulmonary function in older persons.

ABSTRACT:

Background

We provide the first examination of mitochondrial DNA (mtDNA) variants and pulmonary function in older persons.

Methods

Cross-sectional associations between mtDNA variants and pulmonary function were evaluated as a combined p-values meta-analysis, using data from two independent cohorts of older persons. The latter included white and black participants, aged ≥70 years, from the Lifestyle Interventions and Independence for Elders study (LIFE) (N = 1247) and the Health, Aging and Body Composition study (Health ABC) (N = 731), respectively. Pulmonary function included the forced expiratory volume in one-second as a Z-score (FEV1z) and the maximal inspiratory pressure (MIP) in cm of water.

Results

In black participants, significant associations were found betwe

SUBMITTER: Vaz Fragoso CA 

PROVIDER: S-EPMC6356103 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature