Prostatic collagen architecture in neutered and intact canines.

ABSTRACT: BACKGROUND:Prostate stiffness and increased collagen content both associate with the presence of urinary symptoms in men but mechanisms responsible, including impact of age and androgens, are unknown. Dogs develop prostate-related urinary dysfunction similar to humans, but mechanisms are also unknown. Mice have been used to examine how prostatic collagen accumulation affects voiding but whether mouse prostatic collagen organization resembles human or dog has not been evaluated. Here, we have constructed the first comprehensive, comparative maps of collagen architecture in canine, human, and mouse prostate and test whether canine prostatic collagen content is increased by aging and reduced by castration. METHODS:Complete transverse prostate sections were stained with picrosirius red and ima

SUBMITTER: Ruetten H 

PROVIDER: S-EPMC6356104 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature