Murine myeloproliferative disorder as a consequence of impaired collaboration between dendritic cells and CD4 T cells.

ABSTRACT: Dendritic cells (DCs) are a key cell type in the initiation of the adaptive immune response. Recently, an additional role for DCs in suppressing myeloproliferation was discovered. Myeloproliferative disorder (MPD) was observed in murine studies with constitutive depletion of DCs, as well as in patients with congenital deficiency in DCs caused by mutations in GATA2 or IRF8 The mechanistic link between DC deficiency and MPD was not predicted through the known biology and has remained an enigma. Prevailing models suggest numerical DC deficiency leads to MPD through compensatory myeloid differentiation. Here, we formally tested whether MPD can also arise through a loss of DC function without numerical deficiency. Using mice whose DCs are deficient in antigen presentation, we find

SUBMITTER: Humblet-Baron S 

PROVIDER: S-EPMC6356150 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature