Epilepsy Associates with Decreased HIF-1α/STAT5b Signaling in Glioblastoma.

ABSTRACT: Epilepsy at presentation is an independent favorable prognostic factor in glioblastoma (GBM). In this study, we analyze the oncologic signaling pathways that associate with epilepsy in human GBMs, and that can underlie this prognostic effect. Following ethical approval and patient consent, fresh frozen GBM tissue was obtained from 76 patient surgeries. Hospital records were screened for the presence of seizures at presentation of the disease. mRNA and miRNA expression-based and gene set enrichment analyses were performed on these tissues, to uncover candidate oncologic pathways that associate with epilepsy. We performed qPCR experiments and immunohistochemistry on tissue microarrays containing 286 GBMs to further explore the association of these candidate pathways and of markers of mesench

SUBMITTER: Berendsen S 

PROVIDER: S-EPMC6356242 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature