The Incorporation of Host Proteins into the External HIV-1 Envelope.

ABSTRACT: The incorporation of biologically active host proteins into HIV-1 is a well-established phenomenon, particularly due to the budding mechanism of viral egress in which viruses acquire their external lipid membrane directly from the host cell. While this mechanism might seemingly imply that host protein incorporation is a passive uptake of all cellular antigens associated with the plasma membrane at the site of budding, this is not the case. Herein, we review the evidence indicating that host protein incorporation can be a selective and conserved process. We discuss how HIV-1 virions displaying host proteins on their surface can exhibit a myriad of altered phenotypes, with notable impacts on infectivity, homing, neutralization, and pathogenesis. This review describes the canonical and emergi

SUBMITTER: Burnie J 

PROVIDER: S-EPMC6356245 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature