Pathway Analysis of Fucoidan Activity Using a Yeast Gene Deletion Library Screen.

ABSTRACT: Fucoidan, the sulfated fucose-rich polysaccharide derived from brown macroalgae, was reported to display some anti-cancer effects in in vitro and in vivo models that included apoptosis and cell cycle arrest. The proposed mechanisms of action involve enhanced immune surveillance and direct pro-apoptotic effects via the activation of cell signaling pathways that remain largely uncharacterized. This study aimed to identify cellular pathways influenced by fucoidan using an unbiased genetic approach to generate additional insights into the anti-cancer effects of fucoidan. Drug⁻gene interactions of Undaria pinnatifida fucoidan were assessed by a systematic screen of the entire set of 4,733 halpoid Saccharomycescerevsiae gene deletion strains. Some of the findings were confirmed using cell cycle

SUBMITTER: Corban M 

PROVIDER: S-EPMC6356313 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature