Marine Polysaccharide-Collagen Coatings on Ti6Al4V Alloy Formed by Self-Assembly.

ABSTRACT: Polysaccharides of marine origin are gaining interest as biomaterial components. Bacteria derived from deep-sea hydrothermal vents can produce sulfated exopolysaccharides (EPS), which can influence cell behavior. The use of such polysaccharides as components of organic, collagen fibril-based coatings on biomaterial surfaces remains unexplored. In this study, collagen fibril coatings enriched with HE800 and GY785 EPS derivatives were deposited on titanium alloy (Ti6Al4V) scaffolds produced by rapid prototyping and subjected to physicochemical and cell biological characterization. Coatings were formed by a self-assembly process whereby polysaccharides were added to acidic collagen molecule solution, followed by neutralization to induced self-assembly of collagen fibrils. Fibril formation res

SUBMITTER: Norris K 

PROVIDER: S-EPMC6356479 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature