Environmental Change-Dependent Inherited Epigenetic Response.

ABSTRACT: Epigenetic modifications are a mechanism conveying environmental information to subsequent generations via parental germ lines. Research on epigenetic responses to environmental changes in wild mammals has been widely neglected, as well as studies that compare responses to changes in different environmental factors. Here, we focused on the transmission of DNA methylation changes to naive male offspring after paternal exposure to either diet (~40% less protein) or temperature increase (10 °C increased temperature). Because both experiments focused on the liver as the main metabolic and thermoregulation organ, we were able to decipher if epigenetic changes differed in response to different environmental changes. Reduced representation bisulfite sequencing (RRBS) revealed differentially methy

SUBMITTER: Weyrich A 

PROVIDER: S-EPMC6356568 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature