Clerodane Diterpenes from the Marine Sponge Raspailia bouryesnaultae Collected in South Brazil.

ABSTRACT: The marine sponge Raspailia bouryesnaultae, collected in South Brazil, was selected for detailed investigation considering the results of a screening that pointed to an in vitro antiproliferative effect against non-small cells of human lung cancer (A549) and anti-herpes activity against Herpes Simplex virus type 1 (KOS and 29R strains) of ethanolic extracts. The fractionation and chemical investigation of the sponge's hexanic fraction led to the isolation and structural elucidation of six clerodane diterpenes. The main component was identified as the already-reported raspailol (1), isolated from a sponge of the same genus collected in New Zealand. The structure of a new diterpene (2) with a rearranged skeleton was established by high-resolution mass spect

SUBMITTER: Lhullier C 

PROVIDER: S-EPMC6356680 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature