Expression of Neural Crest Markers GLDC and ERRFI1 is Correlated with Melanoma Prognosis.

ABSTRACT: Regulation of particular genes during the formation of neural crest (NC) cells is also described during progression of malignant melanoma. In this context, it is of paramount importance to develop neural crest models allowing the identification of candidate genes, which could be used as biomarkers for melanoma prognosis. Here, we used a human induced Pluripotent Stem Cells (iPSC)-based approach to present novel NC-associated genes, expression of which was upregulated in melanoma. A list of 8 candidate genes, based on highest upregulation, was tested for prognostic value in a tissue microarray analysis containing samples from advanced melanoma (good versus bad prognosis) as well as from high-risk primary melanomas (early metastasizing versus non or late-metastasizing). CD271, GLDC, and ERRF

SUBMITTER: Jager K 

PROVIDER: S-EPMC6356846 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature