Rotavirus Double Infection Model to Study Preventive Dietary Interventions.

ABSTRACT: Rotaviruses are the main cause of acute diarrhea among young children worldwide with an increased frequency of reinfection. Several life style factors, such as dietary components, may influence such processes by affecting the outcome of the first rotavirus infection and therefore having a beneficial impact on the anti-rotavirus immune responses during any subsequent reinfections. The aim of this research was to develop a double-infection model in rat that mimics real-life clinical scenarios and would be useful in testing whether nutritional compounds can modulate the rotavirus-associated disease and immune response. Three experimental designs and a preventive dietary-like intervention were conducted in order to achieve a differential response in the double-infected animals compared to the

SUBMITTER: Rigo-Adrover MDM 

PROVIDER: S-EPMC6357201 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature