Identification of long non-coding RNA-related and -coexpressed mRNA biomarkers for hepatocellular carcinoma.

ABSTRACT: BACKGROUND:While changes in mRNA expression during tumorigenesis have been used widely as molecular biomarkers for the diagnosis of a number of cancers, the approach has limitations. For example, traditional methods do not consider the regulatory and positional relationship between mRNA and lncRNA. The latter has been largely shown to possess tumor suppressive or oncogenic properties. The combined analysis of mRNA and lncRNA is likely to facilitate the identification of biomarkers with higher confidence. RESULTS:Therefore, we have developed an lncRNA-related method to identify traditional mRNA biomarkers. First we identified mRNAs that are differentially expressed in Hepatocellular Carcinoma (HCC) by comparing cancer and matched adjacent non-tumorous liver tissues. Then, we performed mRNA-

SUBMITTER: Zhang F 

PROVIDER: S-EPMC6357343 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature