Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review.

ABSTRACT:

Background

Genetic polymorphisms in genes involved in pain modulation have been reported to be associated to opioid efficacy and safety in different clinical settings.

Methods

The association between COMT Val158Met polymorphism (rs4680) and the inter-individual differences in the response to opioid analgesic therapy was investigated in a cohort of 87 Italian paediatric patients receiving opioids for cancer pain (STOP Pain study). Furthermore, a systematic review of the association between opioid response in cancer patients and the COMT polymorphism was performed in accordance with the Cochrane Handbook and the Prisma Statement.

Results

In the 87 paediatric patients, pain intensity (total time needed to reach the lowest possible level) was significantly higher for G/G

SUBMITTER: Lucenteforte E 

PROVIDER: S-EPMC6357360 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature