InTAD: chromosome conformation guided analysis of enhancer target genes.

ABSTRACT:

Background

High-throughput technologies for analyzing chromosome conformation at a genome scale have revealed that chromatin is organized in topologically associated domains (TADs). While TADs are relatively stable across cell types, intra-TAD activities are cell type specific. Epigenetic profiling of different tissues and cell-types has identified a large number of non-coding epigenetic regulatory elements ('enhancers') that can be located far away from coding genes. Linear proximity is a commonly chosen criterion for associating enhancers with their potential target genes. While enhancers frequently regulate the closest gene, unambiguous identification of enhancer regulated genes remains to be a challenge in the absence of sample matched chromosome conformation data.

Results</

SUBMITTER: Okonechnikov K 

PROVIDER: S-EPMC6357397 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature