Conserved regulation of RNA processing in somatic cell reprogramming.

ABSTRACT:

Background

Along with the reorganization of epigenetic and transcriptional networks, somatic cell reprogramming brings about numerous changes at the level of RNA processing. These include the expression of specific transcript isoforms and 3' untranslated regions. A number of studies have uncovered RNA processing factors that modulate the efficiency of the reprogramming process. However, a comprehensive evaluation of the involvement of RNA processing factors in the reprogramming of somatic mammalian cells is lacking.

Results

Here, we used data from a large number of studies carried out in three mammalian species, mouse, chimpanzee and human, to uncover consistent changes in gene expression upon reprogramming of somatic cells. We found that a core set of nine splicing factors

SUBMITTER: Kanitz A 

PROVIDER: S-EPMC6357513 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature