Detecting differential DNA methylation from sequencing of bisulfite converted DNA of diverse species.

ABSTRACT: DNA methylation is one of the most extensively studied epigenetic modifications of genomic DNA. In recent years, sequencing of bisulfite-converted DNA, particularly via next-generation sequencing technologies, has become a widely popular method to study DNA methylation. This method can be readily applied to a variety of species, dramatically expanding the scope of DNA methylation studies beyond the traditionally studied human and mouse systems. In parallel to the increasing wealth of genomic methylation profiles, many statistical tools have been developed to detect differentially methylated loci (DMLs) or differentially methylated regions (DMRs) between biological conditions. We discuss and summarize several key properties of currently available tools to detect DMLs and DMRs from sequencin

SUBMITTER: Huh I 

PROVIDER: S-EPMC6357555 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature