Identification and characterization of HIV-specific resident memory CD8⁺ T cells in human lymphoid tissue.

ABSTRACT: Current paradigms of CD8⁺ T cell-mediated protection in HIV infection center almost exclusively on studies of peripheral blood, which is thought to provide a window into immune activity at the predominant sites of viral replication in lymphoid tissues (LTs). Through extensive comparison of blood, thoracic duct lymph (TDL), and LTs in different species, we show that many LT memory CD8⁺ T cells bear phenotypic, transcriptional, and epigenetic signatures of resident memory T cells (T_RMs). Unlike their circulating counterparts in blood or TDL, most of the total and follicular HIV-specific CD8⁺ T cells in LTs also resemble T_RMs Moreover, high frequencies of HIV-specific CD8⁺ T_RMs with skewed clonotypic profiles relativ

SUBMITTER: Buggert M 

PROVIDER: S-EPMC6357781 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature