Drug development for cryptococcosis treatment: what can patents tell us?

ABSTRACT:

Background

Cryptococcosis is one of the most devastating fungal infections in humans. Despite the disease's clinical importance, current therapy is based on limited antifungals that are either toxic, inefficient, unavailable worldwide, or that quickly lead to resistance.

Objectives

The goal of this study was to provide insight into the future of cryptococcosis treatment by describing the patent scenario in this field.

Methods

We identified and analysed patent documents revealing compounds with anti-cryptococcal activity supported by experimental evidence.

Findings

Patenting in this field has been historically low, with an overall tendency of increase since 2012. Most applications are single filings, suggesting that they do not encompass strategic inventions req

SUBMITTER: Santos-Gandelman J 

PROVIDER: S-EPMC6358010 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature