Aging of Antiviral CD8⁺ Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing.

ABSTRACT: Aging of established antiviral T cell memory can foster a series of progressive adaptations that paradoxically improve rather than compromise protective CD8⁺ T cell immunity. We now provide evidence that this gradual evolution, the pace of which is contingent on the precise context of the primary response, also impinges on the molecular mechanisms that regulate CD8⁺ memory T cell (T_M) homeostasis. Over time, CD8⁺ T_M generated in the wake of an acute infection with the natural murine pathogen lymphocytic choriomeningitis virus become more resistant to apoptosis and acquire enhanced cytokine responsiveness without adjusting their homeostatic proliferation rates; concurrent metabolic adaptations promote increased CD8⁺ T_M</

SUBMITTER: Davenport B 

PROVIDER: S-EPMC6358025 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature