Circulating antioxidants and Alzheimer disease prevention: a Mendelian randomization study.

ABSTRACT:

Background

Higher circulating antioxidant concentrations are associated with a lower risk of late-onset Alzheimer disease (AD) in observational studies, suggesting that diet-sourced antioxidants may be modifiable targets for reducing disease risk. However, observational evidence is prone to substantial biases that limit causal inference, including residual confounding and reverse causation.

Objectives

In order to infer whether long-term circulating antioxidant exposure plays a role in AD etiology, we tested the hypothesis that AD risk would be lower in individuals with lifelong, genetically predicted increases in concentrations of 4 circulating antioxidants that are modifiable by diet.

Methods

Two-sample Mendelian randomization analyses were conducted. First, publishe

SUBMITTER: Williams DM 

PROVIDER: S-EPMC6358036 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature