Early Childhood Outcomes After Neonatal Encephalopathy in Uganda: A Cohort Study.

ABSTRACT:

Background

Neonatal encephalopathy (NE) is a leading cause of global child mortality. Survivor outcomes in low-resource settings are poorly described. We present early childhood outcomes after NE in Uganda.

Methods

We conducted a prospective cohort study of term-born infants with NE (n = 210) and a comparison group of term non-encephalopathic (non-NE) infants (n = 409), assessing neurodevelopmental impairment (NDI) and growth at 27-30 months. Relationships between early clinical parameters and later outcomes were summarised using risk ratios (RR).

Findings

Mortality by 27-30 months was 40·3% after NE and 3·8% in non-NE infants. Impairment-free survival occurred in 41·6% after NE and 98·7% of non-NE infants. Amongst NE survivors, 29·3% had NDI including 19·0% with cere

SUBMITTER: Tann CJ 

PROVIDER: S-EPMC6358042 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature