Role of SpaO in the assembly of the sorting platform of a Salmonella type III secretion system.

ABSTRACT: Many bacterial pathogens and symbionts use type III secretion machines to interact with their hosts by injecting bacterial effector proteins into host target cells. A central component of this complex machine is the cytoplasmic sorting platform, which orchestrates the engagement and preparation of type III secreted proteins for their delivery to the needle complex, the substructure of the type III secretion system that mediates their passage through the bacterial envelope. The sorting platform is thought to be a dynamic structure whose components alternate between assembled and disassembled states. However, how this dynamic behavior is controlled is not understood. In S. Typhimurium a core component of the sorting platform is SpaO, which is synthesized in two tandemly translated products,

SUBMITTER: Lara-Tejero M 

PROVIDER: S-EPMC6358110 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature