Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction.

ABSTRACT: Much of the computational power of the mammalian brain arises from its extensive top-down projections. To enable neuron-specific information processing these projections have to be precisely targeted. How such a specific connectivity emerges and what functions it supports is still poorly understood. We addressed these questions in silico in the context of the profound structural plasticity of the olfactory system. At the core of this plasticity are the granule cells of the olfactory bulb, which integrate bottom-up sensory inputs and top-down inputs delivered by vast top-down projections from cortical and other brain areas. We developed a biophysically supported computational model for the rewiring of the top-down projections and the intra-bulbar network via adult neurogenesis. The model ca

SUBMITTER: Adams W 

PROVIDER: S-EPMC6358160 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature