Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects.

ABSTRACT: Serine proteases (SPs) and serine protease homologs (SPHs) play essential roles in insect physiological processes including digestion, defense and development. Studies of insect genomes, transcriptomes and proteomes have generated a vast amount of information on these proteins, dwarfing the biological data acquired from a few model species. The large number and high diversity of homologous sequences makes it a challenge to use the limited functional information for making predictions across a broad taxonomic group of insects. In this work, we have extensively updated the framework of knowledge on the SP-related proteins in Drosophila melanogaster by identifying 52 new SPs/SPHs, classifying the 257 proteins into four groups (CLIP, gut, single- and multi-domain SPs/SPHs), and detecting inher

SUBMITTER: Cao X 

PROVIDER: S-EPMC6358214 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature