Analytical validity of a genotyping assay for use with personalized antihypertensive and chronic kidney disease therapy.

ABSTRACT: Hypertension and chronic kidney disease are inextricably linked. Hypertension is a well-recognized contributor to chronic kidney disease progression and, in turn, renal disease potentiates hypertension. A generalized approach to drug selection and dosage has not proven effective in managing these conditions, in part, because patients with heterogeneous kidney disease and hypertension etiologies are frequently grouped according to functional or severity classifications. Genetic testing may serve as an important tool in the armamentarium of clinicians who embrace precision medicine. Increasing scientific evidence has supported the utilization of genomic information to select efficacious antihypertensive therapy and understand hereditary contributors to chronic kidney disease progression. Giv

SUBMITTER: Collins KS 

PROVIDER: S-EPMC6358457 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature