Chemotherapy in older adult gynecologic oncology patients: Can a phenotypic frailty score predict tolerance?

ABSTRACT:

Objective

Evaluate the ability of an office-administered phenotypic frailty assessment to predict chemotherapy tolerance in older adult gynecologic oncology patients, and describe practice patterns for chemotherapy administration in this population.

Methods

Prospective, single-institution cohort study of gynecologic oncology patients 65 or older initiating chemotherapy. Phenotypic frailty testing at an office visit encompassed components of two validated frailty assessments: Fried Score (physical testing and patient response) and FRAIL Scale (patient response only). Patients were followed through three cycles of neoadjuvant chemotherapy or six cycles of adjuvant chemotherapy. Standard statistics examined the relationship of frailty to chemotherapy regimen, ability to complet

SUBMITTER: Hay CM 

PROVIDER: S-EPMC6358476 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature