Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi.

ABSTRACT:

Objective

Nonalcoholic steatohepatitis (NASH) is closely associated with metabolic syndrome and increases the risk for end-stage liver disease, such as cirrhosis and hepatocellular carcinoma. Despite this, the molecular events that influence NASH pathogenesis remain poorly understood. The objectives of the current study are to delineate the transcriptomic and proteomic signatures of NASH liver, to identify potential pathogenic pathways and factors, and to critically assess their role in NASH pathogenesis.

Methods

We performed RNA sequencing and quantitative proteomic analyses on the livers from healthy and diet-induced NASH mice. We examined the association between plasma levels of TSK, a newly discovered hepatokine, and NASH pathologies and reversal in response to dietary s

SUBMITTER: Xiong X 

PROVIDER: S-EPMC6358550 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature