Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease.

ABSTRACT:

Objective

Congenital heart disease (CHD) is the most frequent birth defect worldwide. The number of adult patients with CHD, now referred to as ACHD, is increasing with improved surgical and treatment interventions. However the mechanisms whereby ACHD predisposes patients to heart dysfunction are still unclear. ACHD is strongly associated with metabolic syndrome, but how ACHD interacts with poor modern lifestyle choices and other comorbidities, such as hypertension, obesity, and diabetes, is mostly unknown.

Methods

We used a newly characterized mouse genetic model of ACHD to investigate the consequences and the mechanisms associated with combined obesity and ACHD predisposition. Metformin intervention was used to further evaluate potential therapeutic amelioration of cardiac

SUBMITTER: Wilmanns JC 

PROVIDER: S-EPMC6358551 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature